Meta-Analysis (MA) combines data from several studies using statistical methods. Investigator bias is minimized due to the systematic and quantitative synthesis of data which, also serves to increase the generalizability of health technology on a defined outcome. The MA approach increases statistical power providing a more complete assessment of an intervention’s impact than would be possible from an individual study.
Network Meta-analysis (NMA) and indirect treatment comparisons are useful in the absence of head-to-head RCTs. NMA is a useful tool to conduct multiple pairwise comparisons which contribute to the overall body of evidence and demonstrate the relative treatment effect between competing interventions.